Final Thesis

Modeling and simulation of microfluidic single-cell cultivation

Key Info

Basic Information

Molecular Simulations and Transformation
Focus/Key Topic:


Researching bacteria and other microorganisms does not only help us understand our world, but it is also essential for design and optimization of a growing number of biotechnological processes. Microfluidics offers new opportunities to this end, since structured channels and chambers with volumes of a few picoliters can be used for catching and cultivating single bacteria. Those can then be investigated for growth, antibiotic resistance or productivity. The research group Microscale Bioengineering at the Forschungszentrum Jülich develops and uses new microfluidic structures for a variety of current topics. The transport processes, e.g. for heat transfer and solute diffusion, in these systems are not yet well characterized. Aim of this project is to create a model, which can simulate such transport processes and quantify their impact on the organisms. The study is carried out in cooperation with the Modeling and Simulation group and will presumably be implemented in COMSOL Multiphysics, a commercial CFD program. In the end the models should enable us to predict the performance of current and future microfluidic designs.

Your Profile:
- Interest in biotechnology
- Student of engineering or natural sciences
- Basic skills in computer simulation and modeling
- Fluent in German or English

We offer:
- Modeling in close relation to the experimental practice
- Interdisciplinarity of research groups (Microfluidics and Modeling) and topics (physics, engineering, biology, ...)
- Using a modern commercial CFD program (CFD Multiphysics)
- Very good infrastructure
- The thesis subject can be customized

Christoph Westerwalbesloh
Doctoral Researcher Microscale Bioengineering and Modeling and Simulation
Institute of Bio and Geosciences
IBG-1: Biotechnology
Forschungszentrum Jülich
52425 Jülich, Germany

Phone: +49 2461 61-9066