Final Thesis

Optimization of pH-sensitive membranes for the usage in an enzymatic reaction

Key Info

Basic Information

Unit:
Chemical Process Engineering
Type:
Masterthesis / Bachelorthesis / Forschungspraktikum for Biotechnologen
Focus/Key Topic:
experimental
Date:
22.12.2017

Contact

Membranes made out of hydrogels have the special ability to react active to external stimuli like the pH-value or temperature and change their permeability for certain substances. The aim of this project is the development of pH-sensitive gel membranes which are able the react indirectly to an organic substrate which is enzymatically converted to an acid. Previous work has shown that a buffer system and bivalent ions are build during the reaction which negatively affect the sensitivity of this membranes. In addition to this, the membranes synthesized until now show a slow switching when the pH-Value is changed. A possibility to overcome this problem is the selective removal of these substances out of the reaction media. To create more dynamic membranes several methods are possible e.g. the synthesis of porous gel membranes offering a higher surface to volume ratio and therefore a faster switching behavior. This project includes: • Synthesis of hydrogel membranes • Investigation of disturbing substances • Method development for the removal of these substances • Synthsis of porous hydrogel membranes • Benchmarking We offer: • Supervision of an experienced assistant • Interdisziplinary work • Room for own ideas • Flexible and innovative working atmosphere If you are interested in this project feel free to write me an email or give me a call. Daniel.Bell@avt.rwth-aachen.de Tel.: 0241 80 47891